Ambience Healthcare Joins Unicorn Club With Series C Raise

Another week, another ambient AI mega-round – this time from none other than Ambience Healthcare and its massive $243M Series C.

Welcome to the unicorn club. The round vaulted Ambience’s valuation to $1.25B, making it the second-highest valued startup in the ambient arena behind Abridge, which was valued at an eye-popping $5.3B during its recent $300M Series E.

  • Funnily enough, a16z led both rounds. We don’t usually see VCs cut a check for a startup then turn around and fund their biggest competitor, but playing both sides is a great way to not lose a race.

Ambience isn’t just a scribe. It’s an ambient AI platform for documentation, coding, and clinical documentation integrity.

  • The platform was “architected with the understanding that health systems are not monolithic enterprises” and adapts to the unique context of different care settings.

If you ain’t first, you’re last. Ambience was one of the only ambient AI players to lean in on the revenue cycle component right out of the gate, and the head start is reflected in the results from head-to-head pilots.

  • During a six month bake-off at Cleveland Clinic (now a happy customer), Ambience saw 80% clinician utilization and an NPS of 60, both the highest by a wide margin.
  • Ambience Co-Founder Nikhil Buduma told us that the secret sauce is the platform’s ability to make clinicians feel like “it’s almost reading their minds,” which is made possible by continuous fine-tuning the model for individual specialties.

Where do we go from here? If the launch of Doximity’s free scribe taught us anything, it’s that documentation is officially a commodity. Ambience’s new funds will help it do everything else.

  • That includes diving deeper into the revenue cycle and clinical trials, as well as moving upstream into taking care of patients outside of the four walls of the clinic.
  • It also includes scaling up operations, and Ambience has already begun hiring dozens of former startup founders to lead its new verticals.

The Takeaway

We’re now in a world where perfect transcripts are table stakes, which means the winners of the ambient AI race will be the companies that can help carry the tasks happening after the clinical conversation. Ambience just bulked up to do some heavy lifting.

Ambience Healthcare Locks In $70M for AI Operating System

Ambience Healthcare just closed $70M in Series B funding to cut away at burnout-inducing manual workflows using the latest advances in generative AI.

Ambience’s carving knife isn’t an AI scribe, a coding solution, or a referral tool, but an “AI operating system” that promises to be all those things at once.

That operating system consists of a holistic suite of genAI applications catering to an impressively broad set of use cases. Each app is customized for dozens of specific specialties, care models, and reimbursement frameworks:

  • AutoScribe: AI medical scribe that works across all specialties
  • AutoRefer: AI referral letter support for both PCPs and specialists
  • AutoAVS: After-visit summary tool that generates custom educational content
  • AutoCDI: Point-of-care clinical documentation integrity assistant that analyzes notes and EHR context to ensure ICD-10 codes, CPT codes, and documentation are aligned

Ambience has kept tight-lipped about both its customer count and LLM provider, but we do know that it as:

  • $100M in total funding since launching in 2020
  • Marquee customers like UCSF, Memorial Hermann, and John Muir Health
  • Investments from Silicon Valley heavyweights like Kleiner Perkins, a16z, and OpenAI (probably a decent hint toward the unrevealed LLM partner)

The newly-raised capital will accelerate Ambience’s product roadmap and allow it to build dedicated support teams for its health system partners.

  • The first product up on that roadmap is AutoPrep, an intelligent pre-charting solution that equips clinicians with suggestions for the visit agenda and potential conditions to screen for.

Ambience’s operating system strategy not only gives it a huge total addressable market, but also positions it apart from well-established competition like Nuance and Augmedix, as well as a hungry pack of genAI up-and-comers such as Nabla and Abridge.

  • A continuously learning OS with “a single shared brain” sounds like a versatile way to break down silos, but the flip side of that coin is that providers looking for an answer to a specific problem might be tempted to go with a more specialized solution.

The Takeaway

Driving adoption of any software is hard. Crafting a beautiful user experience is hard. Tailoring a continuously learning AI operating system to every medical specialty sounds extremely hard. At the end of the day, Ambience’s approach is about as ambitious as it gets, but it carries massive advantages if it can execute.

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