Artificial Intelligence

Hidden Flaws Behind High Accuracy of Clinical AI

Nature Journal

AI is getting pretty darn good at patient diagnosis challenges… but don’t bother asking it to show its work.

A new study in npj Digital Medicine pitted GPT-4V against human physicians on 207 image challenges designed to test the reader’s ability to diagnose a patient based on a series of pictures and some basic clinical background info.

  • Researchers at the NIH and Weill Cornell Medicine then asked GPT-4V to provide step-by-step reasoning for how it chose the answer.
  • Nine physicians then tackled the same questions in both a closed-book (no outside help) and open-book format (could use outside materials and online resources).

How’d they stack up?

  • GPT-4V and the physicians both scored high marks for accurate diagnoses (81.6% vs. 77.8%), with a statistically insignificant difference in performance. 
  • GPT-4V bested the physicians on the closed-book test, selecting more correct diagnoses.
  • Physicians bounced back to beat GPT-4V on the open-book test, particularly on the most difficult questions.
  • GPT-4V also performed well in cases where physicians answered incorrectly, maintaining over 78% accuracy.

Good job AI, but there’s a catch. The rationales that GPT-4V provided were riddled with mistakes – even if the final answer was correct – with error rates as high as 27% for image comprehension.

The Takeaway

There could easily come a day when clinical AI surpasses human physicians on the diagnosis front, but that day isn’t here quite yet. Real care delivery also doesn’t bless physicians with a set of multiple choice options, and hallucinating the rationale behind diagnoses doesn’t cut it with actual patients.

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